Bypassing AMPK Phosphorylation
نویسندگان
چکیده
منابع مشابه
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.
AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates glucose transport mediated by cellular stress or pharmacological agonists such as 5-aminoimidazole-4-carboxamide 1 beta-d-ribonucleoside (AICAR). AS160, a Rab GTPase-activating protein, provides a mechanism linking AMPK signaling to glucose uptake. We show that AICAR increases AMPK, acetyl-CoA carboxylase, and AS160 ...
متن کاملChloroquine increases phosphorylation of AMPK and Akt in myotubes
AIMS There are reports that ataxia telangiectasia mutated (ATM) can activate the AMP-activated protein kinase (AMPK) and also Akt, two kinases that play integral parts in cardioprotection and metabolic function. We hypothesized that chloroquine and resveratrol, both known ATM activators, would also activate AMPK and Akt. MAIN METHODS Phosphorylation of AMPK and Akt was assessed after C2C12 my...
متن کاملEffect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
AMP-activated protein kinase (AMPK) responds to oxidative stress. Previous work has shown that ethanol treatment of cultured hepatoma cells and of mice inhibited the activity of AMPK and reduced the amount of AMPK protein. Ethanol generates oxidative stress in the liver. Since AMPK is activated by reactive oxygen species, it seems paradoxical that ethanol would inhibit AMPK in the hepatoma cell...
متن کاملBypassing Greeklish!
The present paper describes a new algorithm for addressing a significant issue: “Greeklish” (or “Greenglish”), which arose by the fact that the Greek language is not fully supported by computer programs and operating systems. In the first section of the paper we describe the “Greeklish” phenomenon and the current situation, in reference also with recent research on it. Some examples are provide...
متن کاملBypassing Malware Defenses
While most other areas of penetration testing are well understood, and their methodologies well documented, little information regarding testing and bypassing malware defenses is available in the public domain. Still, malware incidents remain the most expensive type of incidents caused by outsiders, while also being the most frequent type of incidents occurring to organizations. In addition, si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2014
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2014.05.003